Using Procalcitonin to Guide Antibiotic Therapy
نویسندگان
چکیده
منابع مشابه
Using Procalcitonin to Guide Antibiotic Therapy
Procalcitonin levels rise in response to systemic inflammation, especially of bacterial origin. Multiple randomized controlled trials have demonstrated that procalcitonin-based algorithms can safely reduce antibiotic use in 2 clinical scenarios. First, in stable, low-risk patients with respiratory infections, procalcitonin levels of <0.25 µg/L can guide the decision to withhold antibiotics or s...
متن کاملClinical outcomes associated with procalcitonin algorithms to guide antibiotic therapy in respiratory tract infections.
CLINICAL QUESTION In patients with respiratory tract infection, is measurement of procalcitonin to guide antibiotic prescriptions associated with reduced antibiotic exposure without increases in all-cause mortality or treatment failure? BOTTOM LINE The measurement of procalcitonin to guide initiation and duration of antibiotic treatment in patients with respiratory tract infections of varying...
متن کاملProcalcitonin to guide duration of antibiotic therapy in intensive care patients: some research questions
Despite more than 10 years of research into the usefulness of procalcitonin therapy, Hausfater is right to point out that ‘its exact place in the diagnostic process remains to be defined’ [2]. Both the articles of McLean and of Christ-Crain and Müller have proposed further study of alternative novel biomarkers [3,4]. Early diagnosis of sepsis linked to timely but limited use of antibiotics rema...
متن کاملProcalcitonin to guide duration of antibiotic therapy in intensive care patients: a randomized prospective controlled trial
INTRODUCTION The development of resistance by bacterial species is a compelling issue to reconsider indications and administration of antibiotic treatment. Adequate indications and duration of therapy are particularly important for the use of highly potent substances in the intensive care setting. Until recently, no laboratory marker has been available to differentiate bacterial infection from ...
متن کاملProcalcitonin levels to guide antibiotic therapy in adults with non-microbiologically proven apparent severe sepsis: a randomised controlled trial
OBJECTIVE Some patients with the phenotype of severe sepsis may have no overt source of infection or identified pathogen. We investigated whether a procalcitonin-based algorithm influenced antibiotic use in patients with non-microbiologically proven apparent severe sepsis. DESIGN This multicentre, randomised, controlled, single-blind trial was performed in two parallel groups. SETTING Eight...
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ژورنال
عنوان ژورنال: Open Forum Infectious Diseases
سال: 2016
ISSN: 2328-8957
DOI: 10.1093/ofid/ofw249